�Pfizer proclaimed that in patients with established centre disease, Lipitor� (atorvastatin ca) 80 mg not only significantly rock-bottom the congener risk of suffering a first cardiovascular event by 19 percent compared to Lipitor 10 mg just also provided a sustained reduction in the endangerment of a subsequent second, third, fourth, and fifth cardiovascular result, according to a subanalysis of the five-year Treating to New Targets (TNT) study.
This subanalysis, designed and completed following the closure of the TNT study, was presented at the 2008 European Society of Cardiology Congress in Munich, Germany.
"The original TNT trial, as with most cardiovascular outcome trials, only evaluated the time to a patient's first-class honours degree cardiovascular upshot and therefore may not have in full accounted for the total clinical benefits achieved by intensive LDL-cholesterol lowering," aforementioned Dr. John LaRosa, president and professor of music at the State University of New York Downstate Medical Center in Brooklyn, New York, and a member of the TNT steering committee. "This subanalysis is of import because patients with heart disease often go on to suffer more than one cardiovascular event."
Any cardiovascular outcome, which was chosen as the termination for this post-hoc subanalysis, was defined as death from heart disease, nonfatal heart attack, resuscitated cardiac arrest, certain types of heart surgery, procedure-related heart attack, chest pain, fatal or nonfatal stroke, peripheral arterial disease or hospitalization due to chronic centre failure.
"These findings hint that patients can benefit from semipermanent therapy with high dosage Lipitor," continued Dr. LaRosa.
In this subanalysis of the TNT study, evaluating patients with established fondness disease (n=10,001), compared to Lipitor 10 mg, Lipitor 80 mg demonstrated:
- 19 percent significant relative peril reduction in a number one cardiovascular case (n=3,082);
- 21 percent significant congenator risk reduction in a subsequent sec cardiovascular event (n=1,516);
- 24 percent significant relation risk diminution in a subsequent third cardiovascular event (n=698);
- 28 percent significant relative hazard reduction in a subsequent fourth cardiovascular event (n=345);
- 29 pct significant congenator risk reduction in a subsequent fifth cardiovascular event (n=197).
"Although the original TNT study was non designed to look at subsequent cardiovascular events, these results ar compelling and suggestive of sustained welfare with Lipitor 80 mg compared with Lipitor 10 mg in patients with heart disease," said Dr. Rochelle Chaiken, vice president of the United States of Pfizer's global cardiovascular and metabolic medical team.
About the TNT Study
The TNT study was an investigator-led test coordinated by an independent steering commission and funded by Pfizer. The study enrolled 10,001 manpower and women with coronary heart disease aged 35 years to 75 age in 14 countries and followed them for an average of five long time. Primary study results were published in The New England Journal of Medicine in 2005.
The primary endpoint of the original TNT study was the occurrence of a first major cardiovascular event, outlined as death from middle disease, nonfatal heart attacks, resuscitated cardiac arrest, or fatal or non-fatal strokes.
In contrast, the termination for this subanalysis was any cardiovascular event, defined as death from fondness disease, nonfatal heart attack, resuscitated cardiac arrest, sealed types of heart surgical procedure, procedure-related heart attack, chest pain, fatal or nonfatal stroke, peripheral arterial disease or hospitalization due to chronic ticker failure.
Lipitor 80 mg is non a starting dose. Lipitor is not approved in all countries to abbreviate the peril of cardiovascular events in patients with existing warmheartedness disease.
Important U.S. Prescribing Information
Lipitor is a prescription medication. It is used in patients with multiple peril factors for heart disease such as family history, high blood pressure, age, low HDL ("good" cholesterin) or smoking to cut the jeopardy of a heart blast and fortuity, certain kinds of tenderness surgery and chest pain sensation.
Lipitor is also secondhand in patients with type 2 diabetes and at least one other danger factor for heart disease such as high stemma pressure, smoking or complications of diabetes, including eye disease and protein in urine, to reduce the risk of heart attack and stroke.
Lipitor is used in patients with existing coronary thrombosis heart disease to reduce the risk of mettle attack, slash, certain kinds of warmheartedness surgery, hospital care for warmheartedness failure, and chest nuisance.
When diet and exercise alone are not enough, Lipitor is used along with a low-fat dieting and exercise to lour cholesterol.
Lipitor is not for everyone. It is not for those with liver problems. And it is not for women who ar nursing, pregnant or may become meaning.
Patients pickings Lipitor should tell their doctors if they feel any new muscle pain or helplessness. This could be a sign of rare simply serious muscular tissue side effects. Patients should tell their doctors near all medications they take. This may help stave off serious do drugs interactions. Doctors should do blood tests to contain liver procedure before and during discussion and crataegus oxycantha adjust the dose. The most vernacular side personal effects are flatulency, constipation, stomach pain and heartburn. They tend to be mild and often go away.
http://www.Lipitor.com
More info
Monday 8 September 2008
Friday 29 August 2008
Mp3 music: Coralie Clement
 Artist: Coralie Clement: mp3 download Genre(s): Other Coralie Clement's discography:  Salle Des Pas Perdus Year: 2002 Tracks: 13 Sounding more like such authoritative '60s French pop vocalists as Jane Birkin and Francoise Hardy - distilled with the breathy bossa nova of Astrud Gilberto -- than her contemporaries, Coralie Clément released her low album in 2002, Salle dES Pas Perdus. The record is a collaborative elbow lubricating oil between her and author/composer/performer - and Coralie's rip brother - Benjamin Biolay, wHO wrote and ordered all of the 12 songs. Born into a melodic rout in Villefranche-sur-Saone, France, Coralie could identify all of the instruments of the orchestra by the age of triplet, studied musical theory at little Phoebe, and at sextuplet, she took up the violin. She never considered herself to be a vocalizer, though. She played out much of her adolescent years audience to the records of Serge Gainsbourg, Birkin, Hardy, the Beatles, and, queerly, Vanessa Paradis. Calling herself a "groupie" of her brother's, she conditioned all of his compositions, and she began to reinterpret his songs, imbuing his poetical ballads with both a fleshly black bile and fun. It wasn't until a much later Paris claver with Biolay that he found this out, when she began to blab his songs back to him as he strummed. He recorded this informal school term, and her first base record volume ensued. |
Pharmavite LLC Says Vitamin B Study Published In JAMA Is Flawed; Vitamins Meant For Prevention, Not Disease Treatment
Tuesday 19 August 2008
Mp3 music: EC8OR
 Artist: EC8OR: mp3 download Genre(s): Other EC8OR's discography:  All of Us Can Be Rich Year: 1997 Tracks: 14 Cologne-bred, Berlin-based Patric C. (aka EC8OR) is one of the most fertile of the younger generation of "digital hardcore" artists combination hard-core breakbeat and gabber techno with elements of punk rock rock, speeding alloy, and observational interference. Recording and playing under a half xII pseudonyms (including Eradicator, E-De Cologne, Irish Coffee, and Test-Tube Boy), Patric C.'s EC8OR work is ordinarily in quislingism with adolescent hood singer Gina D'Orio (formerly of the Lemonbabies and Throw That Beat), and through their association with Alec Empire's Digital Hardcore Recordings label, they've managed to turn ane the near pop and well-known artists on the German hard-core scene. Using merely an Amiga 500 (a garish, jolly boat disused screen background computer with built-in sequencing and sampling capabilities), Patric began recording in 1991 after quitting school to immerse himself in the emergent fustian scene. Releasing tracks literally out of his journey bag, Patric's low gear twelves of comparatively straightforward techno appeared through Cologne's noted Structure label mathematical group (which included imprint's such as DJ Ungle Fever, Mono Tone, and Profan along with artists such as Mike Ink, Air Liquide, and Biochip C.). Patric's sexual beloved of blame music, punk, and death alloy didn't picture through and through in the music until he began making breakbeat gabber, however -- a style which linked him with hardcore sulfurous and techno labels such as Shockwave, Fischkopf (through which he released his debut LP, Agitprop), and, eventually, DHR. The group's association with the latter label has belike been the most crucial; in plus to a number of singles and the self-titled EC8OR uncut (released in late 1995), DHR's distribution deal with American label Grand Royal translated into a far larger interview for their music, with Earth Beaters following in 1998. Two days afterward EC8OR released the full-length The One and Only High and Low. |
Films getting head start at boxoffice
Saturday 9 August 2008
Amy Winehouse discharged
Washington (ANI): Troubled vocalist Amy Winehouse has been discharged from hospital after being tempered for reaction to medicine.
The Rehab star was rushed to London's University College Hospital after hurt an adverse reaction to medication yesterday. Winehouse's UK rep Chris Goodman aforesaid that the 24-year-old singer was now in good spirits after spending a 'comfortable night' in hospital.
"She had a bit of a scare yesterday because of a reaction to treatment," Contactmusic quoted Goodman, as saying. "She was unbroken in overnight purely for observation," he added.
More info
The Rehab star was rushed to London's University College Hospital after hurt an adverse reaction to medication yesterday. Winehouse's UK rep Chris Goodman aforesaid that the 24-year-old singer was now in good spirits after spending a 'comfortable night' in hospital.
"She had a bit of a scare yesterday because of a reaction to treatment," Contactmusic quoted Goodman, as saying. "She was unbroken in overnight purely for observation," he added.
More info
Tuesday 1 July 2008
DMX Arrested Again -- We Give Up Already
That's right, woodchuck-chuckers -- it's Groundhog Day!DMX was arrested for the -- oh heck, we lost count how many-ith time -- busted in Miami for trying to buy cocaine and marijuana.
X, real name Earl Simmons, was popped back on June 23 for driving without a valid driver's license ... and on May 9 on seven misdemeanor counts of animal cruelty and four felony drug possession charges ... and May 7 on charges of racing on a highway, reckless driving, two counts of endangerment, three counts of criminal speed and driving on a suspended license.
See Also
Tuesday 24 June 2008
Wednesday 18 June 2008
Police accused of breaking copyright laws
Lancashire Police may have to pay substantial damages after the Performing Rights Society accused them of breaking copyright laws.
The PRS claim that the force have been playing music in their stations, parties and staff gyms and to callers on the phones without possessing the correct license.
The copyright organisation has now taken the matter to the High Court in London, asking for damages and an injunction after Lancashire Police, along with 11 other police forces, refused to pay them.
A license to play music may be needed if music is audible to others, which constitutes a public performance in the eyes of the PRS.
Ars Technica reports that the PRS demanded �200,000 of damages from Kwik-Fit in 2007 because of the volume of some of their mechanics' radios.
The PRS claim that the force have been playing music in their stations, parties and staff gyms and to callers on the phones without possessing the correct license.
The copyright organisation has now taken the matter to the High Court in London, asking for damages and an injunction after Lancashire Police, along with 11 other police forces, refused to pay them.
A license to play music may be needed if music is audible to others, which constitutes a public performance in the eyes of the PRS.
Ars Technica reports that the PRS demanded �200,000 of damages from Kwik-Fit in 2007 because of the volume of some of their mechanics' radios.
Subscribe to:
Posts (Atom)